British Society of Blood and Marrow Transplantation and Cellular Therapy

an organisation for those with a professional interest in haematopoietic cell transplantation and cellular therapies

Module 4: ALLOGENEIC STEM CELL TRANSPLANTS

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The first ever allogeneic Haematopoietic Stem Cell Transplant (HSCT) registered with the BSBMTCT in the UK, took place on 4^th September 1974: It was performed at Charing Cross Hospital, for Bone Marrow Failure: Acquired (Aplastic Anaemia). The donor was an identical sibling (Allograft ID Sib). This transplant was also the first allograft using an identical sibling registered in the UK & RoI

Since then, things have progressed a tremendous amount with around 1700 allogeneic HSCTs reported to the BSBMTCT every year. In Module 4 we will focus on allogeneic HSCT, the terminology and procedures. Donor stem cells are always used in allogeneic transplants so as well as looking at the different donor sources, we will also look at the treatments, tests and complications that these can entail. Hopefully, by the end of this module you will have a good basic knowledge of what an allogeneic HSCT is and be able to recognise key phases and conditions within the patients records thus assisting with data collection and form completion.

In essence this module aims to help the reader:

Become familiar with the allogeneic HSCT process
Become familiar with the HSCT terminology
Become familiar with the tests and scans performed prior to transplant
Be able to decipher the information needed for completion of the EBMT Registry Data Collection Forms (formerly MedA, MedB forms)
Identify scales used to assess patients
Basic understanding of cytogenetics
Basic understanding of molecular markers
Understand stem cell sources
Understand basic donor selection/match
Understand the importance of patient follow up

The BSBMTCT Induction Manual is a flexible e-learning platform which allows you to study at your own pace. There is a short quiz at the end of this module to help you reflect on any knowledge you have acquired. Upon completion of the quiz a printable certificate will be issued, which you can also store within your user profile.

Interspersed throughout the module are links to articles, and media which you may find of further interest. These mixed media inclusions have been added as a further resource on the topics covered within this module and offer a more in depth look at them.