BSBMTCT CTC (Clinical Trials Committee)- IMPACT 2017


The Clinical Trials Committee (CTC) of the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT) in partnership with the IMPACT BMT Clinical Trials Network is making the second call for outline proposals from prospective UK Chief Investigators for innovative early phase clinical trials in allogeneic and autologous stem cell transplantation.

The IMPACT BMT Trials Network consists of 22 UK centres committed to delivering a number of high quality, practice-changing clinical trials with the Cancer Research UK Clinical Trials Unit (CRCTU) at the University of Birmingham being the network hub.

IMPACT will particularly focus on randomised Phase II and Phase III trials addressing a variety of important issues in stem cell transplantation including transplant conditioning, graft-versus-host disease, post-transplant disease management and supportive care.  Proposals must be readily deliverable in a multi-centre format within the UK BMT network.   Proposals are expected for, but are not restricted to the most common indications for transplant including acute leukaemia, myeloma and lymphoma.  Studies investigating stem cell transplants in non-malignant disorders can also be considered.  Collaboration with industry is encouraged.

Outline proposals should be submitted to the BSBMTCT CTC for initial informal discussion with the BSBMTCT CTC Chair and the Medical Director of IMPACT.  There will be at least two calls for proposals per year. Selection of proposals for funding by IMPACT will follow a formal process of competitive external review with successful proposals to be automatically adopted into the NIHR trials portfolio.  It is expected that 3 trials per year over a 4 year period will be approved.

Our aim is to support a structure and culture in the UK of collaborative research which effectively and efficiently delivers transplant trials that improve patient care.  Please feel free to contact us if we can do anything to help.


Ram Malladi

(CTC Chair)

Victoria Potter

(CTC Secretary)

Prof Ronjon Chakraverty

(IMPACT Medical Director)

Dr Victoria Potter

(IMPACT Deputy Medical Director)

Dr Wendy Ingram

(IMPACT Deputy Medical Director)

IMPACT Website:


SOP for Retrospective BSBMTCT Registry Studies FINAL –
please see SOP for Retrospective BSBMT Registry Studies

CTC Authorship policy – please see CTC_AUTHORSHIP_POLICY_Jan_09

CTC Study Proposal Template – please see BSBMT_CTC_Study_Proposal_Template-2017

CTC Study Chair Commitment For Studies Document – please see BSBMT CTC Study Chair Commitment For Studies

Upcoming BSBMT CTC and CTC/IMPACT Meeting Agendas

Please click below to download the agenda for upcoming meetings

The next CTC/IMPACT Meeting is Friday 17th May 2019 in Birmingham more details can be found

Past BSBMT CTC and CTC/IMPACT Meeting Agendas

Please click below to download the agenda for previous meetings already held

BSBMT Clinical Trials Committee Agenda No 50 14th March 2019

CTC-IMPACT Nov 23 agenda_FINAL

CTC-IMPACT March 17 meeting agenda


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